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Magnesium oxide (MgO) is a common mineral supplement often used as an osmotic laxative (drawing water into the intestines) or an antacid.
The term “ozonated magnesium oxide” (or “oxygenated magnesium oxide”) refers to a form of MgO that has been treated with ozone (O₃) or with additional oxygenation steps. Proponents claim that this enhances its cleansing, oxidative, or detoxifying abilities.
Magnesium oxide is osmotic: it draws water into the intestinal lumen, softening stool and increasing volume, which stimulates peristalsis (intestinal contractions). Healthline+3PMC+3WebMD+3
In many guidelines and reports, magnesium oxide is accepted as safe and effective for short-term relief of constipation. PMC+2WebMD+2
However, because it increases water content, too high doses may lead to diarrhea or cramping. WebMD+2Healthline+2
A meta-analysis of trials found that magnesium supplementation led to a modest reduction in BMI (body mass index) in certain subgroups. PubMed
Observational studies report that higher dietary magnesium intake is inversely associated with risk of obesity and lower fasting insulin levels. PMC+1
Magnesium oxide, is available in capsule form, is commonly used to help a number of concerns, ranging from simple low magnesium levels to more specific concerns, like the following:
Relief of Indigestion and Heartburn
Magnesium oxide may be used as an antacid to relieve indigestion and heartburn.
Relief from Constipation and Irregularity
Magnesium oxide causes the intestines to release water into the stool, which softens the stool and relieves constipation and irregularity. A dose of 250 milligrams can be repeated every 12 hours until you find relief.
Relief from Migraine
Studies have shown that patients with migraine, including cluster headaches and menstrual migraine, often have low levels of magnesium, and taking supplements like magnesium oxide may be helpful. Studies suggest that magnesium ions provided by magnesium oxide interrupt the brain signals that may cause migraine. A dose of 400–500 milligrams per day may be required to be effective. This dose may also cause diarrhea as a side effect, but this can usually be controlled by starting with a smaller dose.
Other Health Benefits
Magnesium offers many other health benefits, but magnesium oxide is not the best source for these benefits. Magnesium oxide has difficulty dissolving in water and is not absorbed into bodily tissues as easily as water-soluble magnesium salts, such as magnesium citrate, magnesium chloride, magnesium lactate, or magnesium malate.
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